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J.Lucy Boyd, Epidemiology, answeredIrritability can occur due to a wide range of reasons. Some people are simply less patient or less able to cope with frustration or interference from others. Irritability can happen because of a physical reason, such as pain, being uncomfortable, or being exhausted. Many people become irritable when they try to sleep in a hot room, for example. Sometimes, irritability is an indicator of a mental health issue. You could possibly be suffering from depression or anxiety. You may be having difficulty coping with the stresses of your job or your relationships, leading to irritable outbursts. If your irritability is new or worsening, you should check with your physician or a mental health provider. Life is so much better when you don't feel irritable all the time.