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Mehmet Oz, MD, Cardiology, answeredThe hydroxycitric acid (HCA) extract from garcinia cambogia blocks fat by inhibiting citrate lyase, a key enzyme that your body needs to make fat from carbohydrates. Usually carbohydrates or sugars that are not used immediately or stored in other forms are converted into fats. When HCA inhibits citrate lyase, the fat-making process is halted and the production of LDL (bad cholesterol) and triglycerides decrease.
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Keith Roach, MD, Internal Medicine, answeredIn animal models, high doses of garcinia suppressed growth of fat cells. This dose caused significant toxicity in rats. One study in humans showed decrease in fat accumulation. This may have to do with effects on hormones, such as leptin and insulin.Helpful? 1 person found this helpful.