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Lawrence Friedman, Gastroenterology, answeredThere are forms of chronic diarrhea that have nothing to do with food but are the result of fluids secreted by the intestine. These are called secretory diarrheas and may rarely be caused by hidden tumors, sometimes in the pancreas, that release chemical messengers telling the bowel to release large amounts of liquid. Microscopic colitis is a more common cause of secretory diarrhea. In this case, the colon looks normal during a colonoscopy, but biopsies show intense inflammation of the colon lining.