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Stacy Wiegman, PharmD, Pharmacy, answeredDepo-Medrol is a brand name version of the generic drug methylprednisolone acetate. It comes in an injectable solution that is generally administered by your doctor. Vials of Depo-Medrol come in strengths of 40 mg./ml or 80 mg./ml. Depo-Medrol is an anti-inflammatory glucocorticoid with a wide range of uses. Most commonly it is used to treat pain and inflammation in your joints caused by arthritis, but it can also be used to relieve allergic reactions, respiratory difficulty and even inflammation due to certain cancers. Depo-Medrol works by suppressing your immune system and inhibiting your body from releasing agents that cause inflammation.