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Mehmet Oz, MD, Cardiology, answeredWhen we get a cold, our chests fill with mucus, causing discomfort, pain, and trouble sleeping. Here are two treatments to get rid of the gunk. Try taking an NAC (N-acetylcysteine) supplement. It’s a decongestant with potent antioxidant activity that will break up mucous and thin it down to help your body get rid of it faster. Available for about $8 in drugstores, take 250 milligrams a day of NAC with or without food. If you’re already experiencing drippy nose, however, you should not take an NAC supplement.Helpful? 1 person found this helpful.