Only take Focalin XR as instructed by your doctor. Using more than your doctor instructs you to could be dangerous, as could using Focalin XR in combination with certain medications. You should check with your doctor about any other medications, prescription or non-prescription, which you might take while on Focalin XR. You should take this medication before breakfast in the morning with a glass of water. If you have trouble swallowing the capsule, you may sprinkle its contents on a spoonful of cool applesauce and swallow the mixture whole. Taking Focalin XR late in the day may affect your ability to sleep. With your doctor’s help, you should monitor your blood pressure as well as any other effects of this medication on your body.