While taking Simvastatin, you should avoid drinking large quantities of alcoholic beverages because they have a tendency to increase the triglyceride levels in your blood. This can lead to a greater risk of damage to your liver. You should also avoid eating grapefruit and drinking grapefruit juice. Both forms of the grapefruit can cause a life-threatening interaction when combined with simvastatin. Because this medication works to lower LDL cholesterol and triglyceride levels in the blood, you should also avoid eating foods that are high in cholesterol and fat.