Nitrostat is one of the brand names for nitroglycerin, a prescription medication. It is used to help prevent angina attacks as well as reduce the pain of current angina attacks caused by coronary artery disease. Nitrostat is included in a class of medications known as vasodilators and nitrates. It works by relaxing your large blood vessels and opening up your smaller arteries and veins, which are found in your hands, feet, and close to your skin's surface. This allows oxygen and blood to flow more easily and reduce the workload of your heart. Nitrostat comes in the form of tablets or pills you put under your tongue (sublingual).