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MediGuard answeredPravastatin can be taken at any time during the day or evening. It is best to take it at the same time every day - this should help you remember to take it to ensure that you receive your daily dose. Pravastatin does have interactions with other medications. Keeping your iGuard profile up-to-date with all of your medications, including over-the-counter medications, vitamins, and supplements will help alert you to these potential interactions. You can also ask your pharmacist to review your medication list for possible drugs interactions.