As with any drug, there are some risks when you take Boniva. Some women run the risk of experiencing some of the more severe side effects that can affect the digestive system, such as swallowing difficulties, severe heartburn or ulcers. The risk of these digestive side effects increases if you do not take Boniva as directed; that is, sitting or standing up, and on an empty stomach with plain water. Allergic reactions to Boniva are rare, but they can occur and can include breathing difficulty. Another less common risk is severe pain in your bones, joints or muscles, which usually goes away after discontinuing use of the drug. Some women who have taken Boniva have experienced serious problems with jaw health, such as complications and infections after dental surgery.