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MediGuard answeredBlack cohosh is not tested or regulated by the FDA. Its safety and effectiveness are not clearly documented. As a result, the potential risks and/or advantages of black cohosh are not well known. Since the use of Black Cohosh and prescription drugs in combination is not well studied, it is still possible that you could experience side effects and or an interaction when Blach Cohosh is used with Labetalol and Norvasc. If you are still concerned about menopause symptoms, you should talk to your primary doctor, cardiologist, or gynecologist before taking this supplement.