Overall, leprosy is not easily catchable. Once treatment with antibiotics begins, a person can no longer spread the disease. In addition, a healthy immune system is often enough to prevent the infection from developing in the first place. Ninety-five percent of people will not get the disease after exposure to the bacteria that cause it. However, when caring for someone with leprosy, it is best to avoid direct contact with rashes and sores and overexposure to respiratory fluids from sneezing and coughing.