Daily aspirin low-dose can interact with other medications. Be sure to mention any of the following: acetazolamide (Diamox); angiotensin-converting enzyme (ACE) inhibitors, such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril, (Aceon), quinapril (Accupril), ramipril (Altace), and trandolapril (Mavik); anticoagulants ('blood thinners'), such as warfarin (Coumadin) and heparin; beta blockers such as atenolol (Tenormin), labetalol (Normodyne), metoprolol (Lopressor, Toprol XL), nadolol (Corgard) and propranolol (Inderal); diuretics ('water pills'); medications for diabetes or arthritis; medications for gout such as probenecid and sulfinpyrazone (Anturane); methotrexate (Trexall); other nonsteroidal anti-inflammatory drugs (NSAIDs) such as naproxen (Aleve, Naprosyn); phenytoin (Dilantin); and valproic acid (Depakene, Depakote). Your doctor may need to change the doses of your medications or monitor you more carefully for side effects.
Aspirin is part of the drug class known as salicylates. You should not take aspirin low-dose if you are currently taking another salicylate. You should also not take aspirin and other over-the-counter painkillers such as nonsteroidal anti-inflammatory drugs (NSAIDs) at the same time. They can interfere with aspirin's ability to reduce your risk of heart attack.
You should also not consume more than three alcoholic beverages every day while taking aspirin low-dose. Doing so increases your risk for liver damage and stomach bleeding.