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Healthwise answeredAntiarrhythmic medicines may be used to return an irregular heartbeat (arrhythmia) to its normal rhythm, prevent an arrhythmia or control the heartbeat during an arrhythmia. These drugs work mostly by slowing the heart rate or by helping stabilize the heart muscle tissue. Many antiarrhythmic medicines have side effects, and many interact with other medicines. A person taking any of these medicines should talk often with his or her doctor.