Question

Arginine

What medications can interact with arginine supplements?

A Answers (2)

  • AStacy Wiegman, PharmD, Pharmacy, answered
    L-arginine can interact with other medications, especially the following:

    - anticoagulants and anti-platelet drugs such as warfarin (Coumadin), heparin, or clopidogrel (Plavix)
    - blood pressure medications
    - blood sugar medications
    - diuretics like spironolactone (Aldactone)
    - esomeprazole (Nexium)
    - estrogens
    - nitrates
    - pain relievers such as aspirin, ibuprofen (Motrin, Advil), and naproxen (Aleve, Anaprox, Naprosyn)
    - PDE5 inhibitors such as Sildenafil (Revatio, Viagra), Vardenafil (Levitra, Staxyn) and Tadalafil (Adcirca, Cialis)
    - progestins
    - ranitidine (Zantac)

    Also, use caution in combining L-arginine with dietary supplements such as: lysine, Ginkgo biloba, garlic, saw palmetto, potassium, and any supplements that can raise blood sugar levels or increase the risk of bleeding. Be sure to tell your doctor about all the medications and supplements you take before taking L-arginine.
  • Arginine may cause low blood pressure. Caution is advised in patients taking herbs or supplements that lower blood pressure.

    Arginine may increase the risk of bleeding when taken with drugs that increase the risk of bleeding. Some examples include aspirin, anticoagulants (blood thinners) such as warfarin (Coumadin®) or heparin, antiplatelet drugs such as clopidogrel (Plavix®), and nonsteroidal anti-inflammatory drugs such as ibuprofen (Motrin®, Advil®) or naproxen (Naprosyn®, Aleve®).

    Arginine may change blood sugar levels. Caution is advised when using medications that may affect blood sugar levels. Patients taking insulin or drugs for diabetes by mouth should be monitored closely by a qualified healthcare professional, including a pharmacist. Medication adjustments may be necessary.

    Arginine may also interact with ACE (angiotensin-converting enzyme) inhibitors, agents that increase potassium levels (including angiotensin II receptor antagonists and heparin), agents used to treat blood disorders, aminophylline, antacids, antibiotics, anticancer agents, anti-inflammatories, antimalarials, antiobesity agents, antiseizure agents, aspirin, cardiac glycosides, cholesterol- and lipid-lowering drugs, contraceptives, cyclophosphamide, cyclosporine, diuretics, estrogens, glucagon, growth hormones, H2 blockers, immunosuppressants, iron salts, isoproterenol, nicotine, nitrates, nitroderivatives, phenylephrine, phosphodiesterase inhibitors, potassium salts, propofol, proton pump inhibitors, sertraline, or spironolactone.

    You should read product labels, and discuss all therapies with a qualified healthcare provider. Natural Standard information does not constitute medical advice, diagnosis, or treatment.

    Copyright © 2012 by Natural Standard Research Collaboration. All Rights Reserved.

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