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Mark Morocco, Emergency Medicine, answeredAccording to the National Institute of Mental Health, some antipsychotic medications do cause weight gain. The newer generation of antipsychotics, which are called atypical antipsychotics, affect one's metabolism, often leading to significant weight gain. While some of the side effects of antipsychotics may disappear after a short while, weight gain is often persistent. Researchers studying side effects of atypical antipsychotic medications in children observed an average weight gain of 19 pounds in only three months. Your doctor can monitor your weight if you are taking atypical antipsychotic medications. This will be especially necessary if you are at risk of developing diabetes or high cholesterol.