Dorzolamide hydrochloride ophthalmic solution, or dorzolamide, is used to treat open-angle glaucoma and hypertension of the eye. Dorzolamide reduces the level of fluid in the eye, and thus reduces the pressure inside of the eye. Dorzolamide is a carbonic anhydrase inhibitor drug that is applied as a topical solution to the eye. This medication requires a doctor’s prescription. Dorzolamide is manufactured under the brand name Trusopt.