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MediGuard answeredCymbalta and Lyrica are sometimes used together. However, using Cymbalta and Lyrica together may increase the risk of excessive sedation. As a result, Cymbalta and Lyrica treatment/dose should be regularly reviewed when these drugs are used together - particularly in elderly or weakened patients. When used together, these medications are usually started at the lowest possible dose and then increased as needed. Talk with your physician about the best dosage combination for you and if the combination would work for your specific condition and symptoms.