Yes. Do not mix Cerebyx (generic name fosphenytoin) with alcohol. Alcohol can cause the levels of the medication to elevate in the blood, increasing side effects. Daily use of alcohol can diminish the effectiveness of Cerebyx resulting, in increased incidence of seizures. Cerebyx may interact negatively with certain medications such as birth control pills. Talk to your doctor about alternate methods to prevent pregnancy while taking Cerebyx.
The following medications can enhance Cerebyx side effects: sulfa drugs (Septra or Bactrim); sedatives (Valium or Librium); antidepressants (Prozac); disulfiram (Antabuse); phenothiazines; prochlorperazine (Compazine); thioridazine (Mellaril); chlorpromazine (Thorazine); methylphenidate (Ritalin, Concerta, Daytrana); barbiturates, such as amobarbital (Amytal), mephobarbital (Mebaral), butabarbital (Butisol), Secobarbital (Seconal) or phenobarbital (Solfoton or Luminal); or medications that reduce stomach acid, including cimetidine (Tagamet), famotidine (Pepcid), ranitidine (Zantac) or nizatidine (Axid).
Other medications reduce the effectiveness of Cerebyx. They include: resperine or carbamazepine (Carbatrol, Tegretol or Epitol). Other medications that interact poorly with Cerebyx, include: blood thinners (Warfarin, Coumadin); furosemide (Lasix); digitoxin (Lanoxin, digitalis); steroid medications (prednisolone); valproic acid (Depakene); theophylline (Elixophyllin, Theobid, Theolair, Theo-Dur, Uniphyl); divalproex sodium (Depakote); antibiotics, such as rifampin (Rifadin, Rifamate, Rimactane) or doxycycline (Adoza, Vibramycin, Doryx); or antidepressants, such as amitriptyline, imipramine (Tofranil, Janimine), clomipramine (Anafranil) or trazodone (Desyrel).