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Mehmet Oz, MD, Cardiology, answeredPhytoceramides are relatively inexpensive -- around $10 for a 30-day supply. Try taking one 350 mg capsule daily with food. You should see your skin begin to soften and smooth out in about four weeks. They are safe for most people, but those with gluten sensitivity may want to look for an alternative. Phytoceramides are commonly wheat-based, and although most gluten is removed, it still may be problematic.Helpful? 9 people found this helpful.