There is currently insufficient available evidence in humans to support the use of black bryony for any indication.Black bryony (Tamus communis) is not currently listed on the U.S. Food and Drug Administration (FDA) "Everything Added to Food in the United States" (EAFUS) database, and its generally regarded as safe (GRAS) status is currently not available.
According to secondary sources, all components of the black bryony plant, including the tubers, are poisonous due to saponin content. Therefore, it is not typically used internally; however, it has been used as a poultice for bruises and inflamed joints. It has been suggested that black bryony be used topically with caution, due to a tendency for the plant to cause painful blisters.
Studies have isolated calcium oxalate deposits and histamines in the berry juice and rhizomes, which may contribute to skin irritation and contact dermatitis associated with black bryony.
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