Asian and Native American women are at an even greater disadvantage. Asians lack the enzyme in their liver to be able to break down alcohol. If you lack that system, then you don't detoxify alcohol as well.
The explanation for this missing enzyme is biological. It might be because in Asian cultures, instead of fermenting their drinkables, like making beer, they would boil the water to make tea. That meant they didn't have to have a system in their liver to get rid of the alcohol. They could just drink their water.