YES. Plaque psoriasis is treated differently depending on the site. That’s because the skin on your elbows is different from the skin on your head. Not to mention, you probably wouldn’t want to put a cream you use for your feet on your face. When the plaque psoriasis affects a small part of the body, topical steroid creams or ointments or light therapy may be used. But when plaque psoriasis is more severe and covers a larger part of your body, injectable drugs or oral medications may be better.