Because sickle-hemoglobin C (Hb S-C) disease is a genetic defect, you are at a greater risk of developing the disorder if your parents were carriers of sickle cell anemia and hemoglobin C disease. If your parents have a family history of these diseases, you could be at risk. In addition, African Americans carry the gene for sickle-cell anemia more frequently than whites. Thus race could be a factor in determining your risk.
Regan Holdridge, MD
- internal medicine
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- What increases my risk for sickle-hemoglobin C (Hb S-C) disease?
How are hemorrhaging disorders inherited?
Genes that are responsible for the production of clotting factors are located on the X chromosomes. Every person has at least one X chromosome; females have two, and males have one. When clotting factor genes are defective or mutated, that gene is passed on to a child, who may then inherit the disorder.
How do I avoid blood clots if I have to fly after major surgery?
Michael Roizen, MD, Internal Medicine, answeredMajor surgery puts you at risk of forming blood clots for up to three months.
A long trip during which you can't move around much impedes circulation in your lower body, which also increases your chances of clots. When a travel-related clot forms, it's often in a deep vein of the leg or pelvis and is called a deep vein thrombosis (DVT). If a clot breaks free and travels to your lungs, it can be fatal. Here's how to lower your DVT risk:
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- Move your butt. Get up every half hour to walk about the cabin. Moving your leg muscles helps "pump" blood.
- Roll and flex. If you can’t get up, roll your ankles and flex and point your toes at least 10 times every half hour to activate your leg muscles.
- Drink lots of water and no alcohol. Do not become dehydrated. It makes blood thicker and more likely to clot.
- Wear compression stockings. They apply graduated pressure on your legs from the ankles up, which keeps blood moving.
- Wear loose clothes (no body shapers), and don't cross your legs. Putting any kinks on lower-body veins inhibits circulation.
- Take two baby aspirin. If your doctor says it's okay, take them with half a glass of water one hour before your flight and every day for three days afterward.