Genes that are responsible for the production of clotting factors are located on the X chromosomes. Every person has at least one X chromosome; females have two, and males have one. When clotting factor genes are defective or mutated, that gene is passed on to a child, who may then inherit the disorder.
Peter Cohen, MD
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- Cleveland Clinic
- How are hemorrhaging disorders inherited?
What is the treatment for a hemorrhaging disorder?
Hemorrhaging disorders are most often treated with intravenous replacement therapy. Replacement therapy involves replacing missing clotting factors in the blood, and it is used as a preventive measure. Other treatment options vary depending on the type and severity of the disorder.
Is it likely that your child would need his or her cord blood?
Discovery Health answered
The likelihood of your child needing his or her cord blood is hard to pin down. A recent article in "Biology of Blood and Marrow Transplantation," estimates the odds are about 1 in 435 that a person would need to use his or her own cells (autologous) in a cord-blood-derived embryonic like (CBE) transplant and at 1 in 400 that he or she would be need an allogeneic CBE transplant (cells from a donor, either relative or stranger).
Other studies, however, have estimated the need for an autologous or an allogeneic transplant at somewhere between from 1 in 2,000 to 1 in 200,000. Essentially, researchers just don't know because CBE stem cell transplantation is still in the experimental stage.
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