Neuropeptidesoriginate in the nervous system and brain (hence, the neuropart), including the peripheral nerve endings in skin. One neuropeptide that gets a lot of attention in research circles is called Substance P. It’s a well-known chemical that promotes pain in the body, and can also increase sebum production (not a good thing if you’re prone to acne).
Substance P may further be a player in depression and anxiety, which are often affiliated with acne. When the body senses stress, nerves, especially nerve endings in the skin, send out Substance P in response. When neuropeptide receptors in skin receive messages, they react by sharing the message out to other cells, which tells them how to function. This is how the feeling of embarrassment can move from your brain to your skin, causing it to blush. Similarly, when you are happy, your skin glows; you are white as a ghost when frightened. It’s as if we were chameleons and can change pretty quickly, what we are thinking and how we are feeling has an outward appearance.
From The Mind-Beauty Connection: 9 Days to Less Stress, Gorgeous Skin, and a Whole New You by Amy Wechsler.