Myelodysplastic/myeloproliferative diseases share characteristics with both myelodysplastic syndromes and myeloproliferative diseases. Myeloproliferative diseases involve the overproduction of blood cells, while myelodysplastic syndromes involve the formation of abnormal blood cells. Myeloproliferative/myeloproliferative diseases include chronic myelomonocytic leukemia, juvenile myelomonocytic leukemia, and atypical chronic myelogenous leukemia. Certain DNA changes lead to uncontrolled cell growth and division and this can lead to the development of myelodysplastic/myeloproliferative diseases.
Mary Reed, MD
Location and Office HoursVia Christi Cancer Center
1102 E Centennial
Pittsburg, KS 66762
What are myelodysplastic/myeloproliferative diseases?
Piedmont Heart Institute answered
What is a hemoglobin electrophoresis test?
A hemoglobin electrophoresis test is a blood test done to check the different types of hemoglobin in the blood. Hemoglobin is the substance in red blood cells that carries oxygen. See a picture of hemoglobin.
The most common types of normal hemoglobin are:
- Hemoglobin A. This is the most common type of hemoglobin found normally in adults. Some diseases, such as severe forms of thalassemia, may cause hemoglobin A levels to be low and hemoglobin F levels to be high.
- Hemoglobin A2. This is a normal type of hemoglobin found in small amounts in adults.
There are more than 350 types of abnormal hemoglobin.
The most common are:
- Hemoglobin S. This type of hemoglobin is present in sickle cell disease.
- Hemoglobin C. This type of hemoglobin does not carry oxygen well.
- Hemoglobin E. This type of hemoglobin is found in people of Southeast Asian descent.
- Hemoglobin D. This type of hemoglobin is present in some sickle cell disorders.
Hemoglobin S and hemoglobin C are the most common types of abnormal hemoglobin that may be found by an electrophoresis test.
Electrophoresis uses an electrical current to separate normal and abnormal types of hemoglobin in the blood. Hemoglobin types have different electrical charges and move at different speeds. The amount of each hemoglobin type in the current is measured.
An abnormal amount of normal hemoglobin or an abnormal type of hemoglobin in the blood may mean that a disease is present. Abnormal hemoglobin types may be present without any other symptoms, may cause mild diseases that do not have symptoms or cause diseases that can be life-threatening. For example, hemoglobin S is found in sickle cell disease, which is a serious abnormality of the blood and causes serious problems.
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When blood is donated, is it tested for AIDS and hepatitis?
Katrina Bramstedt, PhD, Health Education, answered
Donor blood is not tested for AIDS, it is tested for HIV (the virus that causes AIDS). Donor blood is also tested for various other pathogens such as strains of viral hepatitis. For more information on all the screening tests that are performed, contact the US Centers for Disease Control (www.CDC.gov).
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