Serotonin, which has been shown to influence many of the brains cells, is made through a biochemical process in the brain but for the most part is found in the digestive tract and in the blood platelets. As a neurotransmitter, Serotonin is responsible for feelings of happiness, contentment and overall mood. When concentration levels of serotonin are high then feelings of happiness ensue. When levels of Serotonin are low an individuals overall mood decreases as they become irritable and sad. Additionally 5-HTP, which can act as a serotonin precursor to stimulate the secretion of serotonin production in the brain. If the levels of serotonin absorbed during reuptake are extreme then this also can lead to feelings of sadness. As a result, serotonin can be linked to have influences on different behaviors such as, but not limited to, overall mood. The overall composition of serotonin is essentially a combination of tryptophan hydroxylase and tryptophan, which makes 5-hydoxytryptamine, also known as serotonin.
Indra S. Gatiwala, MD
- sleep medicine
Location and Office HoursNeurology Center Of Lumberton
Lumberton, NC 28358
- BC/BS of North Carolina
- CIGNA HealthCare
- Great-West Healthcare CIGNA
- PARTNERS National Health Plans
- United Healthcare
- Southeastern Regional Medical Center
What are the effects of different levels of serotonin?
Sharine Forbes, Gerontology, answered
Who is at risk for neuromyelitis optica?
Multiple Sclerosis Foundation answeredThe relapsing form of neuromyelitis optica (NMO) primarily affects women. The female to male ratio is greater than 4:1. Another form of NMO, in which an individual only has a single, severe attack extending over a month or two, is most likely a distinct disease that affects men and women with equal frequency. The onset of NMO varies from childhood to adulthood with two peaks, one in childhood and the other in adults in their 40s.
According to Mayo Clinic neurologist Dean Wingerchuk, MD, the prevalence and incidence of NMO have not been firmly established. “It has a worldwide distribution, and reported risk factors include females and non-Caucasian racial background,” says Dr. Wingerchuk. “Population-based studies of clinically diagnosed NMO have indicated prevalence rates from 0.32-4.4 cases per 100,000 population. In aggregate, the data suggests that there are likely more than 4,000 people with NMO in the United States, and possibly more than 10,000.” This means government or national funding is not assigned to researching NMO because not enough people in the U.S. have been diagnosed with this disease.
What might cause a pins-and-needles sensation in my fingers?
Anthony Komaroff, MD, Internal Medicine, answeredThe sensation of "pins and needles" is usually due to a nerve problem.
The medical term is parathesias. It may also include shooting pains, numbness or a heavy feeling in an arm or leg. Common causes include:
- Nerve compression
- Vitamin B12 deficiency (which impairs nerve function)
Carpal tunnel syndrome is due to the compression of a major nerve (called the median nerve) that travels through a narrow area (the carpal tunnel) in the wrist. Besides pins and needles, some people experience weakness, particularly in the thumb.
Repetitive motion may be a risk factor for carpal tunnel syndrome. But studies that looked at people who use repetitive hand or wrist motions have been mixed on whether their risk of carpal tunnel syndrome is truly increased.
Treatment options for carpal tunnel syndrome include:
- Treating or removing any underlying trigger
- Wearing a splint that keeps the wrist relatively straight
- Cortisone injections
- Surgery (as a last resort)
Find out more about this book:Harvard Medical School Arthritis: Keeping your joints healthy
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