Chronic myeloproliferative disorders are a type of bone marrow disease in which too many precursor, or blood-producing, cells develop in the bone marrow. Normally, the bone marrow produces blood stem cells that eventually develop into mature blood cells. But in chronic myeloproliferative disorders, the stem blood cells turn into excessive red blood cells, white blood cells, or platelets.
Barry S. Skikne, MD
Location and Office HoursUniversity of Kansas Medical Center Hematology Oncology
2330 Shawnee Mission Pkwy Ste 3303
Mission, KS 66205
- BlueCross BlueShield of Kansas City
- Kansas City VA Medical Center
- University of Kansas Hospital & Medical Center
- What are chronic myeloproliferative disorders?
How does hemolytic-uremic syndrome affect the body?
Hemolytic-uremic syndrome (HUS) affects the body by attacking and damaging red blood cells. When the red blood cells (including the platelets in your blood which help you clot) are damaged, they do not travel properly through your veins. The misshapen cells get stuck in small veins and cause blockages that affect the functioning of your body, most commonly the kidneys. When blood flow to the kidneys is blocked it inhibits your kidneys' ability to remove extra fluid and waste from your body, causing swelling, reduced urine production, and elevated blood pressure.
When your platelets are damaged, your blood's ability to clot, or create a scab, is affected and you bleed very easily. The inability to clot can mimic symptoms of anemia and cause extreme fatigue and blood loss.
Can I donate blood if I have had a blood transfusion?
American Red Cross answered
In the United States is necessary for you to wait for 12 months after receiving a blood transfusion from another person. You may not donate blood if you received a blood transfusion after 1980 in the United Kingdom (England, Wales, Scotland, Northern Ireland, Channel Islands, Isle of Man, Gibraltar or Falkland Islands). This requirement is related to concerns about variant CJD, or ‘mad cow’ disease. You may not donate blood if you have received a blood transfusion after 1977 in certain countries in Africa. This requirement is related to concerns about rare strains of HIV that are not consistently detected by all current test methods.
Guidelines on eligibility to give blood change from time to time. The most up-to-date eligibility information can be obtained by contacting the American Red Cross blood center nearest you.
See all Blood Basics questions